HIGH RESOLUTION STRUCTURES OF ACIDIC MAMMALIAN CHITINASES AND USES THEREOF

摘要

High resolution structures of acidic mammalian chitinase (AMCase) are disclosed. The structures disclosed herein enable selection of, and structure-based rational drug design of, agents that modulate, e.g., antagonize, AMCase activity. Thus, crystal compositions, methods of selecting and/or designing agents, e.g., antagonists, of AMCase, and computer and software programs are disclosed.