| 摘要 |
<p>Disclosed is a therapeutic agent for MLL leukemia or MOZ leukemia, which comprises an inhibitor of an M-CSF receptor as an active ingredient. Also disclosed is a method for the screening of a pharmaceutical composition which can inhibit the expression or activity of an M-CSF receptor and, therefore, can treat or prevent leukemia. Further disclosed is a method for the detection of leukemia, which involves the step of measuring the expression level of an M-CSF receptor. It is found that an M-CSF receptor (M-CSFR, CSF1R, c-FMS, CD115) is highly expressed in a cell having an activity of inducing MLL leukemia or MOZ leukemia (which is an intractable type of leukemia) (i.e., a leukemic stem cell), in other words, an M-CSF receptor signal is closely related to the onset of leukemia.</p> |
