| 主权项 |
1. A method of treating an ALDH-mediated disorder selected from alcohol intolerance, alcohol addiction, alcohol abuse disorder, methanol poisoning, and ethylene glycol monomethyl ether poisoning, the method comprising administering to individual in need thereof a compound Formula I: wherein: each of R1, R2, and R3 is independently selected from H, a halo, a substituted or unsubstituted phenyl group, an aliphatic group, an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group, a substituted or unsubstituted cyclic group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heteroaryl group; A is C or S, wherein a=1 when A=C, and a=2 when A=S; Ar1 is selected from a substituted heterocyclic group, an unsubstituted heterocyclic group, a substituted aryl group, an unsubstituted aryl group, a substituted heteroaryl group, and an unsubstituted heteroaryl group; and Ar2 is a substituted pyridine oxide; or a pharmaceutically acceptable salt, an analog, or a derivative thereof. |
