发明名称 |
Methods of modulating adrenomedullin by administering an anti-adrenomedullin (ADM) antibody |
摘要 |
Patients having a chronic or acute disease or acute condition may be in need for stabilizing the circulation. Subject matter of the present invention is an anti-Adrenomedullin (ADM) antibody or an anti-adrenomedullin antibody fragment or an anti-ADM non-Ig scaffold for use in therapy of acute disease or condition of a patient for stabilizing the circulation.;In a preferred embodiment anti-ADM antibody or an anti-adrenomedullin antibody fragment or an anti-ADM non-Ig scaffold according to the present invention reduces the vasopressor requirement, e.g. catecholamine requirement of said patient. The catecholamine requirement of a patient is an indicator for the condition of the circulation and hemodynamic function of said patient. |
申请公布号 |
US9402900(B2) |
申请公布日期 |
2016.08.02 |
申请号 |
US201214358506 |
申请日期 |
2012.11.16 |
申请人 |
ADRENOMED AG |
发明人 |
Bergmann Andreas |
分类号 |
A61K39/395;C07K16/26;G01N33/68;A61K31/137;A61K45/06;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
Millen White Zelano and Branigan, PC |
代理人 |
Millen White Zelano and Branigan, PC |
主权项 |
1. A method of modulating the activity of adrenomedullin in a subject comprising administering an anti-adrenomedullin (anti-ADM) antibody or anti-ADM antibody fragment, wherein said antibody or antibody fragment binds to a region of at least 4 amino acids within the sequence of aa 1-42 of mature human ADM: YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVA (SEQ ID NO: 24), wherein said antibody or fragment does not bind to the C-terminal portion of ADM (aa 43-52 of ADM (SEQ ID NO: 25)), and wherein the subject is in need of stabilization of the systemic circulation. |
地址 |
Hennigsdorf DE |