| 主权项 |
1. A compound of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: R1 is H, D, F, Cl, CN, —NH2, —NHCH3, —N(CH3)2, —OH, —OCH3, —OCH2CH3, —OCH2CH2OH, imidazolyl, pyrazolyl, oxetanyl, azetidinyl, or C1-C3 alkyl; R2, R3 and R4 are independently H, D, F, Cl, —NH2, —NHCH3, —N(CH3)2, —OH, —OCH3, —OCH2CH3, —OCH2CH2OH, or C1-C3 alkyl; R5 is optionally substituted C6-C20 aryl, C3-C12 carbocyclyl, C2-C20 heterocyclyl, C1-C20 heteroaryl, —(C6-C20 aryl)-(C2-C20 heterocyclyl), —(C1-C20 heteroaryl)-(C2-C20 heterocyclyl), —(C1-C20 heteroaryl)-(C1-C6 alkyl), or —(C1-C20 heteroaryl)-C(═O)—(C2-C20 heterocyclyl); R6 is H, F, —NH2, —OH, or optionally substituted C1-C3 alkyl; X is S, S(═O), S(═O)2, N, NR6, O, or CR7; R7 is independently H, D, F, Cl, —CH3, —CH2CH3, —CN, —CH2F, —CHF2, —CF3, —NH2, —OH, or —OCH3; Y1 and Y2 are independently CR6 or N; Z1, Z2, Z3, and Z4 are independently C, CR7, or N; Z5 is —C(R3)2C(R3)2—, —C(R3)2C(═O)—, —CR3═CR3—; one of Z1 and Z2, or X and Z1, where X is not S, S(═O), or S(═O)2, forms a five-, six-, or seven-membered aryl, carbocyclyl, heterocyclyl or heteroaryl ring; where alkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally independently substituted with one or more of D, F, Cl, Br, I, —CH3, —CH2CH3, —CH2CH(CH3)2, —CH2OH, —CH2CH2OH, —C(CH3)2OH, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CH2OP(O)(OH)2, —CN, —CH2F, —CHF2, —CF3, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CON(CH3)2, —C(CH3)2CONH2, —NO2, —NH2, —NHCH3, —N(CH3)2, —NHCOCH3, —N(CH3)COCH3, —NHS(O)2CH3, —N(CH3)C(CH3)2CONH2, —N(CH3)CH2CH2S(O)2CH3, ═O, —OH, —OCH3, —OCH2CH2N(CH3)2, —OP(O)(OH)2, —S(O)2N(CH3)2, —SCH3, —CH2OCH3, —S(O)2CH3, cyclopropyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, oxetanyl, or morpholino. |
