| 摘要 |
Peptide compound (I), is new. New peptide has formula (I): W1>-X1>N-Arg-X2>-Asp-Leu-X3>-X4>-Leu-X5>-X6>m-W2> (I); X1>-X6>amino acid residue chosen from Ala, Asn, Asp, Arg, Cys, Gln, Glu, Gly, Phe, His, Ile, Leu, Lys, Met, Nle, homo-Phe, Phg, Pro, Ser, Thr, Trp, Tyr or Val, and known amino acid derivatives; Nle : norleucine; Phg : phenylglycine; W1>H or Ac; W2>OH, OR, NHR, NR2, NH2; R : 1-6C alkyl; and n, m : 0 - 15. ACTIVITY : Cardiant; thrombolytic; cytostatic; osteopathic; antiinflammatory; antipsoriatic; antiarteriosclerotic. MECHANISM OF ACTION : alpha vbeta 6 Integrin Receptor Inhibitor. |
