发明名称 |
PROCESSO PER LA PREPARAZIONE DI 2-ALOGENOMETIL-PENEMS E LORO USO PER LA PREPARAZIONE DI PENEMS ANTIBATTERICI |
摘要 |
<p>Process for the preparation of 2-halomethyl-penems (I) comprising (a) reacting an acetoxy-(protected hydroxyethyl)-2-azetidinone (III) with a 2-halothioacetic acid to form a 3-haloacetylthioazetidinone (V), (b) reacting (V) with oxalyl chloride to give an intermediate (VII), acylated on the beta-lactamic nitrogen, and (c) cyclizing (VII) in the presence of an organic phosphate or phosphonite to produce the corresponding 2-halomethyl-penem (I).</p> |
申请公布号 |
ITFI960033(D0) |
申请公布日期 |
1996.02.27 |
申请号 |
IT1996FI00033 |
申请日期 |
1996.02.27 |
申请人 |
A.MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. |
发明人 |
ALTAMURA MARIA |
分类号 |
C07D499/883;C07D205/09;C07D499/88;C07D499/887 |
主分类号 |
C07D499/883 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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