摘要 |
A class of substituted aminocyclohexane derivatives are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1D alpha receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT1D alpha receptor subtype relative to the 5-HT1D beta subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists.
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申请人 |
MERCK SHARP & DOHME LIMITED;MACLEOD, ANGUS, MURRAY;SHOWELL, GRAHAM, ANDREW;STREET, LESLIE, JOSEPH |
发明人 |
MACLEOD, ANGUS, MURRAY;SHOWELL, GRAHAM, ANDREW;STREET, LESLIE, JOSEPH |