发明名称 |
Use of mutated macrolide binding protein for the prevention of GVHD |
摘要 |
This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating host versus graft disease following blood marrow transplantation by transfecting stem cells so that after introduction into a patient the stem cells will express the modified cyclophilin, and, as necessary, administer the modified cyclosporin A to the patient. |
申请公布号 |
WO9808956(A3) |
申请公布日期 |
1998.06.18 |
申请号 |
WO1997US15153 |
申请日期 |
1997.08.27 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;THE LELAND S. STANFORD JUNIOR UNIVERSITY;SCHREIBER, STUART, L.;BELSHAW, PETER, J.;CRABTREE, GERALD |
发明人 |
SCHREIBER, STUART, L.;BELSHAW, PETER, J.;CRABTREE, GERALD |
分类号 |
C12N15/09;A01K67/027;A61K31/35;A61K38/00;A61K48/00;A61P7/00;A61P37/00;C07K7/64;C07K14/47;C07K14/715;C12N5/10;C12N9/16;C12N9/90;C12N15/54 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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