| 摘要 |
PROBLEM TO BE SOLVED: To obtain a measuring chip whose sensitivity is good and which can be manufactured with good efficiency by a method wherein a functional group is introduced into the surface of metal colloidal particles and the metal colloidal particles are arranged on a substrate in a most densely filled manner. SOLUTION: A measuring chip is formed in such a way that metal colloidal particles 2 into which a functional group is introduced are arranged on a substrate 1. As the substrate 1, a material which is used usually as a measuring chip for an optical analyzer and which is transparent with reference to a laser beam, e.g. a glass or a plastic, is used. The thickness of the substrate 1 is preferably at about 0.1 to 5mm. In the colloidal particles 2, the functional group is introduced into the surface of the metal colloidal particles, and metal particles in a size of a colloidal size region (10 to 1000nm) are used. As a metal for the metal colloidal particles, gold, platinum, silver or the like is used, but gold is preferable. When the colloidal particles 2 which are prepared in this manner are used, a physiologically active substance which is coupled to the functional group is fixed to a position near a metal colloid, and the measuring sensitivity of the measuring chip can be enhanced.
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