METHOD FOR PREPARING 1-PHENYL-2,3-DIMETHYL-4-IODOPYRAZOLONE-5 (IODOANTIPYRINE)

摘要

FIELD: organic chemistry, chemical technology, pharmacy. ^ SUBSTANCE: invention relates to a method for synthesis of 1-phenyl-2,3-dimethyl-4-iodopyrazolone-5 (iodoantipyrine) representing a medicinal preparation. Invention proposes a method for synthesis of iodoantipyrine by electrophilic iodination of antipyrine or antipyrine benzene sulfoacid under conditions of mechanical activation without solvent being both at the synthesis step and the isolation step. Using the proposed method provides preparing pharmacopoeia iodoantipyrine with the yield 57-96% depending on the parent substrate and an iodinating reagent, significant simplifying the process for its synthesis and the complete excluding an organic solvent. ^ EFFECT: improved method of synthesis. ^ 4 ex