COMBINATION THERAPY FOR TOPICAL APPLICATION IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND OCULAR HYPERTENSION

摘要

A topical drug composition for the treatment of age-related maculopathy, age-related macular degeneration, ocular hypertension, glaucoma or other eye disease resulting from increased intraocular pressure comprising a solution of anabolic androgenic agent and 17-ß-estradiol suspended or dissolved in a suitable ophthalmic vehicle is disclosed. In the preferred embodiment, 17-ß-estradiol, or its esters, is in a lipid vehicle or 17-ß-estradiol-3-phosphate, or other esters of 17-ß-estradiol, is combined with an anabolic androgenic agent in an aqueous vehicle having a pH of between about pH 6 to pH 8. The composition is administered to the eye in an effective amount to maintain physiologic or normal intraocular pressure or to return elevated intraocular pressure to lower levels.