METHOD FOR SCREENING OF INTERACTION INHIBITORS BETWEEN YAP OR TAZ PROTEIN AND MAML1 OR MAML2 PROTEIN

摘要

The present invention relates to a method for screening interaction inhibitors between YAP or TAZ protein and MAML(mastermind-like)1 or MAML2 protein. More specifically, when MAML1 or MAML2 is interacting with YAP or TAZ and occurrence of MAML1/2 is inhibited, transcriptional activation of the YAP or TAZ is inhibited and WW domain of the TAZ and PPxY sequence of the MAML1/2 are confirmed to play an important role in mutual interaction, and when expression of the MAML1 is inhibited, movement of the YAP in a nucleus is inhibited and movement of a cell is inhibited. The inhibitors capable of inhibiting interaction between the YAP/TAZ and the MAML1/2 through the screening method according to the present invention prevents the YAP/TAZ from moving toward the nucleus, thereby usefully used for inhibiting formation of cancer.