Method for producing cereulide and derivative thereof, intermediate for production of cereulide, and cereulide derivative

摘要

The purpose of the present invention is to provide a novel method for producing cereulide and a derivative thereof; an intermediate for cereulide; and a novel cereulide derivative. A novel didepsipeptide, a novel tetradepsipeptide, a novel octadepsipeptide and a novel dodecadepsipeptide are prepared. A linear precursor of cereulide or a derivative thereof, which is composed of any one of the novel depsipeptides, is cyclized by forming an intramolecular amide bond.

主权项

1. A cereulide derivative represented by the following formula: wherein R represents (CH2)2COOH or (CH2)2CONH(CH2)5COOH.