Phenicol antibacterial agents

摘要

The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical compositions containing these novel compounds, and methods for the preparation of these compounds.

主权项

1. A compound of formula I wherein R1 is —H, —C(O)—R3, —C1-C6 alkyl, or —CN; R2 is -C1-C6 alkyl optionally substituted with one to three halo, or —C3-C6 cyclopropyl; R3 is —C1 —C6 alkyl; W is  or absent; X and Y are each independently halo; Z is —C1-C2 alkyl-, —C3-C4 cycloalkyl- or absent; or an isomer thereof, or a pharmaceutical acceptable salt thereof.