Methods of treatment using a BCAT1 inhibitor

摘要

The present invention is directed to BCAT inhibitors with the following formula:;Wherein R1 is a linear alkyl group and X+ denotes a cation. These inhibitors are useful in treating autoimmune inflammatory diseases such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, psoriasis and inflammatory bowel disease.

主权项

1. A method for treating an autoimmune inflammatory disease in a subject, comprising administering to a subject having an autoimmune inflammatory disease a therapeutically effective amount of a BCAT1 inhibitor and a pharmaceutically acceptable carrier,
where the BCAT1 inhibitor is selected from the group of compounds encompassed by formula (1): where R1 is a linear alkyl group and X+ denotes a cation, and where the autoimmune inflammatory disease is selected from the group consisting of systemic lupus erythematosus, rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, and inflammatory bowel disease.