发明名称 |
HUMANIZED IMMUNOGLOBULIN REACTING SPECIFICALLY WITH Fas LIGAND OR ACTIVE FRAGMENTS THEREOF AND REGION INDUCING APOPTOSIS ORIGINATING IN Fas LIGAND |
摘要 |
<p>Novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are provided, and a site on Fas ligand which is important to inhibit apoptosis induced by the Fas-Fas ligand interaction against Fas-expressing cells is demonstrated. The novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are prepared from hybridomas which produce monoclonal antibodies specifically reactive to Fas ligand, via recombinant DNA techniques. The humanized immunoglobulins can inhibit the physiological reactions between Fas ligand and Fas such as typically apoptosis. Further, identification of the site which is on Fas ligand and responsible for apoptosis induction allows to create recombinant proteins or peptides which are specifically reactive to the amino acids within the site so as to inhibit apoptosis, and to find new therapeutic or diagnostic agents. <IMAGE></p> |
申请公布号 |
EP0957166(A1) |
申请公布日期 |
1999.11.17 |
申请号 |
EP19970937807 |
申请日期 |
1997.08.27 |
申请人 |
SUMITOMO ELECTRIC INDUSTRIES, LTD. |
发明人 |
OKUMURA, KO;NAKATA, MOTOMI;HIGUCHI, HIROFUMI;USHIO, YOSHITAKA;MAEDA, HIROAKI;EDA, YASUYUKI |
分类号 |
C07K14/705;C07K16/28;C12N15/13;C12P21/08;(IPC1-7):C07K16/28;A61K39/395 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|