DOMAIN-MODIFIED CONSTANT REGION ANTIBODIES

摘要

An antibody having at least one binding site region and a domain-modified constant region is provided wherein the domain-modified constant region is a substitution, duplication, or deletion of substantially all of the amino acids of at least one of the domains of the constant region. The functional properties of the domain-modified constant region antibodies are altered to enhance the desired biological functions for a particular application. DNA sequences encoding constructs expressing domain-modified constant region antibody heavy chains and cells expressing domain-modified constant region antibodies are also provided.