REMEDIAL AGENT FOR ANXIETY NEUROSIS OR DEPRESSION AND PIPERAZINE DERIVATIVE

摘要

A remedy for anxiety neurosis or depression which contains an MC4 receptor antagonist as the active ingredient; and a piperazine derivative represented by the formula [1] or a pharmaceutically acceptable salt thereof, wherein Ar<1> represents (un)substituted phenyl, etc.; Ar<2> represents (un)substituted naphthyl, quinolyl, a group represented by the formula [a] (wherein R<4> is hydrogen or halogeno; and X-Y is CH-NH, CH-O, CH-S, or N-O), or a group represented by the formula [b] (wherein R<5> is hydrogen, hydroxy, or C1-10 alkoxy); R<1> represents hydrogen, C1-10 alkyl, etc.; R<2> and R<3> are the same or different and each is hydrogen or C1-10 alkyl; A-B represents N-CH2, CH-CH2, C(OH)-CH2, or C=CH; T<1> represents a single bond, -O-, etc.; and n is an integer of 1 to 10.