GASTRIN COMPOUND FOR DIABETES TREATMENT

摘要

The invention relates to compositions and methods for the prevention or treatment of diabetes, comprising a therapeutically effective amount of at least one gastrin compound ie gastrin G1. The gastrin compound provides beneficial effects comprising the control of haemoglobin AIc (HbA1c), fasting blood glucose, glucose levels or insulin levels. The subjects which are treated with the compositions and methods of the invention are selected based on baseline HbA1c levels or based on existing treatment with a glucose lowering agent with or without an insulin sensitivity enhancer, in particular, a metformin with or without a thiazolidinedione. The use of a gastrin compound for decreasing HbA1c levels in a diabetic subject is also proposed.