主权项 |
1. A compound of the formulawherein:
A is R is independently one or more hydrogen, CD3, halogen, haloalkyl, hydroxyalkyl, CN, CF3, CH2F, CHF2, optionally substituted (C1-C6)alkyl, optionally substituted (C1-C6)alkoxy, optionally substituted (C3-C6)cycloalkyl, optionally substituted heterocyclo, —CONR3R4, —NR3R4, NR3R4(C1-C6)alkyl-, —NR6OCOR3, —NR6COR3, NR6COR3(C1-C6)alkyl-, —NR6CO2R3, NR6CO2R3(C1-C6)alkyl-, —NR6CONR3R4, —SO2NR3R4, SO2(C1-C6)alkyl-, —NR6SO2NR3R4, —NR6SO2R4 or NR6SO2R4(C1-C6)alkyl-; X and Y are independently selected from hydrogen, optionally substituted (C1-C6)alkyl, optionally substituted (C3-C8)cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclo; Z is hydrogen, halogen, —OH, (C1-C6)alkyl, (C1-C6)alkoxy, —NR3R4, —CONR3R4, —OCONR3R4, —NR6OCOR3, —NR6CONR3R4, —NR6SO2NR3R4 or —NR6SO2R4; R1 is, independently at each occurrence, one or more hydrogen, halogen, —CN, —OR4, —NR3R4, —CONR3R4, —COOH, —OCONR3R4, —NR6OCOR3, —NR6CONR3R4, —NR6SO2NR3R4, —NR6SO2R4, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkoxy, optionally substituted (C3-C8)cycloalkyl, optionally substituted (C3-C8)cycloalkyl (C1-C6)alkyl, optionally substituted (C3-C8)cycloalkyl-CO—, optionally substituted (C3-C8)cycloalkyl-SO2—, optionally substituted aryl (C1-C6)alkoxy, optionally substituted (C3-C8)cycloalkyl (C1-C6)alkoxy, optionally substituted heterocyclyl-CO—, optionally substituted heterocyclyl, optionally substituted (C1-C6)alkyl-SO2—, —NR6SO2-optionally substituted (C1-C6)alkyl, —NR6SO2-optionally substituted heterocyclo, optionally substituted (C1-C6)alkyl-NR6SO2— or optionally substituted heterocyclo-NR6SO2—; R2 is hydrogen, halogen, —CN, OH, —CONR3R4, —NR6COOR4, —NR6CONR3R4, —NR6COR4, —NR6SO2R5, —SO2NR3R4, —NR6SO2NR3R4, optionally substituted (C1-C6)alkyl, optionally substituted (C3-C8)cycloalkyl, optionally substituted (C1-C6) alkoxy, optionally substituted aryl, optionally substituted (C1-C6)alkyl-SO2—, optionally substituted aryl-S02, optionally substituted heteroaryl or optionally substituted heterocyclo; R3 is hydrogen, optionally substituted (C1-C6)alkyl, optionally substituted (C3-C8)cycloalkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, cyano(C1-C6)alkyl, hydroxy(C1-C6)alkyl, optionally substituted aryl, optionally substituted aryl(C1-C6)alkyl, optionally substituted aryloxy(C1-C6)alkyl, optionally substituted (C1-C6)alkyl-SO2—, optionally substituted heterocyclyl, optionally substituted heterocyclyl(C1-C6)alkyl, optionally substituted heteroaryl or optionally substituted heteroaryl(C1-C6)alkyl, R4 is hydrogen, optionally substituted (C1-C6)alkyl or optionally substituted (C3-C8)cycloalkyl; or R3 and R4 may be taken together with the nitrogen atom to which they are attached to form an optionally substituted (C4-C8) heteroaryl or (C4-C8) heterocyclic ring; R5 is hydrogen, optionally substituted (C1-C6)alkyl, optionally substituted (C3-C8)cycloalkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, cyano(C1-C6)alkyl, hydroxy(C1-C6)alkyl, optionally substituted aryl, optionally substituted aryl(C1-C6)alkyl, optionally substituted aryloxy(C1-C6)alkyl, optionally substituted (C1-C6)alkyl-SO2—, optionally substituted heterocyclyl, optionally substituted heterocyclyl(C1-C6)alkyl, optionally substituted heteroaryl or optionally substituted heteroaryl(C1-C6)alkyl; R6 is hydrogen or optionally substituted (C1-C6)alkyl; R7 is hydrogen, optionally substituted (C1-C6)alkyl, CN or halogen; and/or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof. |