Bis-quaternary cinchona alkaloid salts as asymmetric phase transfer catalysts

摘要

The invention is directed to novel bis-quarternary cinchona alkaloid salts and the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis. The present invention is directed to novel bis-quarternary cinchona alkaloid salts and the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis. On certain substrates and under specific reaction conditions, the inventors have discovered that the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis surprisingly provides for a more active and efficient process as compared to mono-quarternary catalysts.

主权项

1. A bis-quaternary alkaloid salt having the chemical structure of Formula II: wherein:
R1 is ethyl or vinyl;R2 is hydrogen or methoxy;Ar1 and Ar2 are defined as follows:I) Ar1 is:  and Ar2 is allyl; or(II) Ar2 is: Ar1 is: (II) Are is: Ar1 is:  or —CH3; and,X and Y are independently a halide anion.