发明名称 |
Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation |
摘要 |
The present invention provides an apparatus for producing a mass-coded combinatorial library comprising a set of compounds having the general formula X(Y)n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1. The apparatus comprises a digital processor assembly for selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 50 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. Methods of use of the mass-coded combinatorial library produced by this apparatus are also disclosed.
|
申请公布号 |
US6721665(B2) |
申请公布日期 |
2004.04.13 |
申请号 |
US20020133109 |
申请日期 |
2002.04.26 |
申请人 |
NEOGENESIS DRUG DISCOVERY, INC. |
发明人 |
BIRNBAUM SETH;WINTNER EDWARD A. |
分类号 |
B01J19/00;C07B61/00;C40B40/06;C40B70/00;(IPC1-7):C06F17/00 |
主分类号 |
B01J19/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|