摘要 |
Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth. |
申请人 |
MINNESOTA MINING AND MFG. CO., SAINT PAUL, MINN., US |
发明人 |
CAPECCHI, JOHN, T., SAINT PAUL, MN 55133-3427, US;HEILMANN, STEVEN, M., SAINT PAUL, MN 55133-3427, US;KREPSKI, LARRY, R., SAINT PAUL, MN 55133-3427, US;KWON, OH-SEUNG, SAINT PAUL, MN 55133-3427, US;OLSON, DAVID, B., SAINT PAUL, MN 55133-3427, US |