摘要 |
<p>The present invention provides a novel method to enhance an ability to suppress in vivo protein synthesis in a method of suppressing synthesis by use of an antisense nucleotide sequence. More specifically, the present invention provides an antisense nucleotide sequence comprising two or more successive repeats of the structural gene of interest or a fragment thereof in the antisense direction, an expression vector comprising said antisense nucleotide sequence, a host transformed by said expression vector and a method for suppressing the expression of a protein by use of said antisense nucleotide sequence.</p> |