ASYMETRIC HYDROGENATION OF BETA- or GAMMA-KETOESTERS AND BETA- or GAMMA-KETOAMIDES
摘要
<p>beta - or gamma -Ketoesters and beta - or gamma -ketoamides are asymmetrically reduced with a Ru(II)-BINAP derived catalyst at about 40 DEG C. and about 50N/mm2 of hydrogen in the presence of a strong acid.</p>
申请公布号
GR3029952(T3)
申请公布日期
1999.07.30
申请号
GR19990400881T
申请日期
1999.04.15
申请人
MERCK & CO., INC.
发明人
ARMSTRONG, JOSEPH, D., III;DIMICHELE, LISA;DOUGLAS, ALAN, W.;KELLER, JENNIFER, L.;KING, STEVEN, A.;THOMPSON, ANDREW, S.;VERHOEVEN, THOMAS, R.
