| 摘要 |
Methods, and apparatus of forming in situ tissue adherent barriers are provided using a sprayer (90) capable of applying two or more viscous cross linking solutions to tissue. The sprayer (90) comprises separate spray nozzles (98, 100) for each of two or more cross linking solutions, wherein each nozzle (98, 100) is in communication with a gas pressurized chamber (48) also may include valves (52) that prevent back flow through the supply lines (99, 101) carrying the cross linking solutions, and a venting system (106, 108) for venting excess pressure for laparoscopic applications. In the presence of gas flow, the cross linking solutions are atomized, and mixed to form a spray. Multi-component hydrogel systems suitable for use with the inventive methods, and apparatus are also described.
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