发明名称 |
Expression and export of interferon-alpha proteins as fc fusion proteins |
摘要 |
Disclosed are nucleic acid sequences, for example, DNA or RNA sequences, which encode an immunoglobulin Fc-Interferon-alpha fusion protein. The nucleic acid sequences can be inserted into a suitable expression vector and expressed in mammalian cells. Also disclosed is a family of immunoglobulin Fc-Interferon-alpha fusion proteins that can be produced by expression of such nucleic acid sequences. Also disclosed are methods of using such nucleic acid sequences and/or fusion proteins for treating conditions, for example, hepatitis, which are alleviated by the administration of interferon-alpha. |
申请公布号 |
AU5031800(A) |
申请公布日期 |
2000.12.05 |
申请号 |
AU20000050318 |
申请日期 |
2000.05.19 |
申请人 |
LEXIGEN PHARMACEUTICALS CORP. |
发明人 |
KIN-MING LO;YAPING SUN;STEPHEN D. GILLIES |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K38/11;A61K38/21;A61K48/00;A61P1/16;A61P31/20;A61P43/00;C07K14/52;C07K14/56;C07K14/715;C07K16/18;C07K19/00;C12N5/10;C12N15/21;C12N15/62;C12N15/63;C12N15/86;C12N15/863;C12P21/02;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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