发明名称 |
Method of inhibiting neurotrophin-receptor binding |
摘要 |
The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75 NTR common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75 NTR comprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys 34 of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys 95 of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys 88 of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys 32 of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile 31 , Phe 101 and Phe 86 of nerve growth factor. |
申请公布号 |
AU4531800(A) |
申请公布日期 |
2000.12.05 |
申请号 |
AU20000045318 |
申请日期 |
2000.05.11 |
申请人 |
QUEENS UNIVERSITY AT KINGSTON |
发明人 |
GREGORY M. ROSS;IGOR L. SHAMOVSKY;SANDRA MARONE;DONALD F. WEAVER;RICHARD J. RIOPELLE |
分类号 |
A61K31/00;A61K31/473;A61P25/28;C07D221/14 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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