VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) NUCLEIC ACID LIGAND COMPLEXES

摘要

PROBLEM TO BE SOLVED: To provide a vascular endothelial growth factor (VEGF) nucleic acid ligand complex.

SOLUTION: There are disclosed a method for preparing a complex comprising a VEGF nucleic acid ligand and a non-immunogenic, high molecular weight compound or lipophilic compound by identifying a VEGF nucleic acid ligand by SELEX methodology and associating the VEGF nucleic acid ligand with a non-immunogenic, high molecular weight compound or lipophilic compound; complexes comprising one or more VEGF nucleic acid ligands in association with a non-immunogenic, high molecular weight compound or lipophilic compound; a lipid construct comprising a VEGF nucleic acid ligand or complex; and methods for making the same.

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