System and method for conditioning the heart using sub-threshold anodal stimulation

摘要

A rules engine acquires sensor data from sensors applied to the heart and determines whether an electrical waveform should be applied to the heart and, if so, the type of electrical waveform. A multi-phase cardiac stimulus generator generates waveforms in response to the rules engine. The electrical waveform is applied to one or more electrodes implanted in or on the heart.

主权项

1. An apparatus for providing electrical therapy to a heart of a patient comprising:
a multi-phase cardiac waveform generator; one or more sensors to sense a condition of the heart; one or more electrodes implanted on or in at least one of an atrial chamber and a ventricular chamber of the heart; and a rules engine to receive data from the one or more sensors and including a memory to store rules and a processor configured to
poll the one or more sensors to obtain sensor data;apply the rules to the sensor data to determine whether to deliver a sub-threshold anodal electrical waveform to at least one of the one or more electrodes, the determination being based on at least a duration of a P-R interval in electrical activity of the heart, the sub-threshold anodal electrical waveform being insufficient to depolarize cardiac tissue and cause contraction thereof;instruct the multi-phase cardiac waveform generator to generate the sub-threshold anodal electrical waveform when delivery of the sub-threshold anodal electrical waveform to at least one of the one or more electrodes is determined;deliver the sub-threshold anodal electrical waveform at a timing determined from the sensor data; andpoll the one or more sensors to obtain additional sensor data after delivery of the sub-threshold anodal electrical waveform to determine whether to continue application of the sub-threshold anodal electrical waveform,wherein the sub-threshold anodal stimulation is delivered to at least the one of the one or more electrodes implanted on or in the atrial chamber after the atrial chamber has contracted.