| 发明名称 | Conjugates of GM-CSF and IL-7, compositions and methods related thereto | ||
| 摘要 | In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acids. | ||
| 申请公布号 | US9375465(B2) | 申请公布日期 | 2016.06.28 |
| 申请号 | US201214355673 | 申请日期 | 2012.11.13 |
| 申请人 | Emory University;Children's Healthcare of Atlanta, Inc. | 发明人 | Galipeau Jacques;Hsieh Hsiang-Chuan |
| 分类号 | A61K38/19;A61K39/00;C07K14/535;C07K14/54;A61K39/39;A61K35/14;A61K38/00 | 主分类号 | A61K38/19 |
| 代理机构 | Emory Patent Group | 代理人 | Emory Patent Group |
| 主权项 | 1. A conjugate comprising a GM-CSF polypeptide and an IL-7 polypeptide, wherein the conjugate comprises the amino acid sequence of SEQ ID NO:1. | ||
| 地址 | Atlanta GA US | ||