| 主权项 |
1. A method for treating a patient suffering from obesity, said method comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of formula (I) or an enantiomer, diastereomer, solvate, or pharmaceutically acceptable salt thereof;wherein:
Y is a heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyridinyl, isoxazolyl, imidazolyl, furazan-3-yl, pyrazolyl, triazolyl, tetrazolyl, and [1,2,3]thiadiazolyl; wherein Y is optionally independently substituted with one to two substituents selected from the group consisting of fluoro, chloro, bromo, C1-4alkyl, cyano, and trifluoromethyl; Z is a heteroaryl selected from the group consisting of indolyl, indazolyl, benzoxazolyl, benzothiazolyl, benzothienyl, benzofuranyl, imidazo[1,2-a]pyridin-2-yl, pyrrolo[2,3-b]pyridinyl, pyrrolo[3,2-b]pyridinyl, thieno[2,3-b]pyridinyl, quinolinyl, quinazolinyl, and benzimidazolyl; wherein said Z is optionally independently substituted with one to two substituents selected from the group consisting of C1-4alkyl, trifluoromethyl, 2,2,2-trifluoroethoxy-methyl, 2,2,2-trifluoroethoxy, trifluoromethylthio, chloro, fluoro, bromo, and iodo;with the proviso that a compound of formula (I) is other than
a compound wherein Y is thiazol-4-yl and Z is 5-fluoro-3H-benzimidazol-2-yl; a compound wherein Y is thiazol-2-yl and Z is 5-fluoro-1H-benzimidazol-2-yl; a compound wherein Y is thiazol-4-yl and Z is 5-chloro-benzofuran-2-yl; a compound wherein Y is isothiazol-5-yl and Z is 6-trifluoromethyl-1H-indol-2-yl; a compound wherein Y is thiazol-4-yl and Z is 5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl; a compound wherein Y is thiazol-2-yl and Z is 8-bromo-6-chloro-imidazo[1,2-a]pyridin-2-yl; or a compound wherein Y is thiazol-2-yl and Z is 6-trifluoromethyl-imidazo[1,2-a]pyridin-2-yl. |
