Toxoid Peptides Derived from Phenol Soluble Modulin, Delta Toxin, Superantigens, and Fusions Thereof

摘要

The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure provides delta toxin and phenol-soluble modulin peptides as well as mutants, fragments, variants or derivatives thereof. The disclosure further provides multivalent oligopeptides, fusion proteins comprising two or more staphylococcal proteins, e.g., DT, PSM, alpha hemolysin, leukocidin, superantigen, or any fragments, variants, derivatives, or mutants thereof fused together as a single polypeptide in any order.

主权项

1. A recombinant peptide comprising a Staphylococcus aureus delta toxin peptide or a mutant, fragment, variant or derivative thereof (DT); a Staphylococcus aureus phenol soluble modulin peptide or a mutant, fragment, variant or derivative thereof (PSM); or a fusion of a DT and a PSM; wherein the peptide is attenuated relative to wild-type DT, PSM, or both, and wherein the peptide can elicit an anti-Staphylococcus aureus immune response when administered to a subject.