BLOOD CLOTTING AGENT SOLUTION, METHOD FOR PRODUCING BLOOD CLOTTING AGENT SOLUTION, AND METHOD FOR PRODUCING LIQUID BLOOD EMBOLIC PROTEIN INTRINSIC COMPOSITION E2P

摘要

A blood clotting agent solution that contains, as an active ingredient, a liquid blood embolic protein intrinsic composition E2P capable of promoting and accelerating blood clotting, said liquid blood embolic protein intrinsic composition E2P being a composition that is obtained by removing Smsp-2 and Smsp-3 and further removing calcium ion from a protein extract of a silk fiber net of a 5th instar larva of Stenopsyche marmorata, has a standardized phosphorylation rate of 36±3%, and comprises lesp-400kDa (Smsp-1) and lesp-14kDa (Smsp-4) wherein the ratio by weight of lesp-400kDa (Smsp-1):lesp-14kDa (Smsp-4) is 9:1. The blood clotting agent solution comprises a solution of the aforesaid liquid blood embolic protein intrinsic composition E2P and a phosphate ion-free buffer that is isotonic to a body fluid. A method for producing the aforesaid blood clotting agent solution and the production of the liquid blood embolic protein intrinsic composition E2P.