| 摘要 |
Pharmaceutical compositions comprising a compound selected from a class of N-substituted ( alpha -imidazolyl-toluyl)pyrrole compounds are described for use in treatment of circulatory disorders. Compositions of particular interest comprise angiotensin II antagonist compounds of the formula wherein m is one; wherein R0 is selected from CH2OH, CO2H, CHO, CO2CH3, CO2C2H5, CH2OCH3, CH2OCHOCH3 and CH2-CO2C2H5; wherein R1 is selected from Cl, CF3, CHO, n-butyl, cyano, CO2CH3 and CO2CH2CH3; wherein R2 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, cyclohexylethyl, propylthio, butylthio and hydroxyalkyl; wherein each of R3, R4, R6, R7, R9 and R10 is hydrido; wherein each of R5 and R8 is independently selected from hydrido, halo, nitro, trifluoromethyl, hydroxy, alkoxy, cyano, carboxyl, methoxycarbonyl with the proviso that at least one of R5 and R8 is an acidic group selected from C02H and tetrazolyl; or a tautomer thereof or a pharmaceutically-aceptable salt thereof. These compositions are particularly useful in treatment or control of hypertension and congestive heart failure.
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