| 发明名称 |
TACE INHIBITORS |
| 摘要 |
A compound of formula (I), wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and Q are as defined, useful in the treatment of arthritis, cancer, and other diseases involving the dysregulated production/release of reprolysins such as TNF and other diseases characterized by matrix metalloproteinase activity. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NASAIDs), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.
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| 申请公布号 |
WO0009492(A1) |
申请公布日期 |
2000.02.24 |
| 申请号 |
WO1999IB01392 |
申请日期 |
1999.08.05 |
| 申请人 |
PFIZER PRODUCTS INC.;MCCLURE, KIM, FRANCIS;NOE, MARK, CARL;LETAVIC, MICHAEL, ANTHONY;CHUPAK, LOUIS, STANLEY |
发明人 |
MCCLURE, KIM, FRANCIS;NOE, MARK, CARL;LETAVIC, MICHAEL, ANTHONY;CHUPAK, LOUIS, STANLEY |
| 分类号 |
A61K31/5355;A61K31/5375;A61K31/5377;A61K31/54;A61P1/00;A61P1/02;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P17/00;A61P19/02;A61P19/10;A61P25/14;A61P25/16;A61P25/24;A61P27/02;A61P29/00;A61P31/04;A61P31/18;A61P35/00;A61P37/00;A61P37/06;A61P37/08;A61P43/00;C07D211/96;C07D265/30;C07D279/12;C07D413/12;(IPC1-7):C07D279/12;A61K31/535;C07D241/24 |
主分类号 |
A61K31/5355 |
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