发明名称 |
METHOD FOR THE IMPROVEMENT OF ISLET SIGNALING IN DIABETES MELLITUS AND FOR ITS PREVENTION |
摘要 |
The present invention discloses a method for therapeutically treating mammals, including but not limited to humans, to increase the relative insulin producing performance of endogenous pancreatic ²-cells and to cause differentiation of pancreatic epithelial cells into insulin producing ²-cells. Oral administration of a DP-IV inhibitor causes the active form of GLP-1 to be preserved longer under physiological conditions. The extended presence of GLP-1, in particular in the pancreatic tissue facilitates differentiation and regeneration of the ²-cells already present that arc in need of repair. These repaired insulin producing cells can contribute to the correction and maintenance of normal physiological glycemic levels. |
申请公布号 |
PT1283735(E) |
申请公布日期 |
2009.03.19 |
申请号 |
PT20010927848T |
申请日期 |
2001.04.02 |
申请人 |
PROSIDION LIMITED |
发明人 |
HANS-ULRICH DEMUTH;KONRAD GLUND |
分类号 |
A61P3/10;C07D277/04;A61K31/00;A61K31/40;A61K31/401;A61K31/425;A61K31/426;A61K38/00;A61K45/00;A61K45/06;A61P3/00;A61P5/00;A61P5/50;A61P19/00;A61P19/02;A61P29/00;A61P31/00;A61P31/18;A61P37/00;A61P37/06;A61P43/00;C07D277/00 |
主分类号 |
A61P3/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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