Ameliorating oxidative stress in neurodegenerative disease via Nox1 targeting

摘要

Disclosed herein are methods, compounds and compositions designed for ameliorating oxidative stress in cells. In particular, disclosed are viral vectors that express RNA interfering molecules for inhibiting expression or activity of Nox1 or RAC1. Depending on the location of administration, expression of inhibiting molecules can reduce oxidative stress in neurons associated with a particular neurodegenerative condition.

主权项

1. A method for treating Parkinson's Disease in a subject, comprising administering to the subject a therapeutically effective amount of a composition that inhibits the expression or action of NADPH oxidase 1 (Nox1) in the subject; wherein the composition comprises an adeno-associated virus (AAV)-mediated RNA interfering molecule targeting Nox1.