Inhibitors of the plasmodial surface anion channel as antimalarials

摘要

Disclosed are inhibitors of the plasmodial surface anion channel (PSAC) inhibitors and the use thereof in treating or preventing malaria in an animal such as a human, comprising administering an effective amount of an inhibitor or a combination of inhibitors. An example of such an inhibitor is a compound of formula I,;
or a pharmaceutically acceptable salt thereof, wherein R1 to R7 are as described herein.

主权项

1. A method of providing prophylaxis to an animal in need thereof against malaria or treating an animal afflicted with malaria comprising administering to the animal an effective amount of a compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof.