Benzoxazine oxazolidinone compound, preparation method and application thereof

摘要

Disclosed are a benzoxazine oxazolidinone compound shown by a general formula (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a preparation method thereof, and an application thereof in preparing a drug for treating an infectious disease and in particular, an infectious disease caused by multidrug resistant bacteria.;

主权项

1. A benzoxazine oxazolidinone compound of formula (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof, wherein, R1 is hydroxyl, wherein, R4 and R5 are each independently H, hydroxyl, C1-C4 straight-chain or branched alkyl, and R4 and R5 are not hydroxyl at the same time; R6 and R7 are each independently H, C1-C4 straight-chain or branched alkyl, or benzyl; R8 is H, C1-C4 straight-chain or branched alkyl, or benzyl; N is 0 or 1; R2 is absent or C1-C4 straight-chain or branched alkyl; R3 is halogen; —CN; C1-C6 straight-chain or branched alkyl substituted by one or more groups selected from the group consisting of hydroxyl, oxo, halogen, amino, C3-C6 cycloalkyl and substituted or unsubstituted 5- or 6-membered aromatic heterocyclic group containing at least one heteroatom selected from N, O or S; 3- to 6-membered cycloalkyl, which is unsubstituted or substituted by amino, C1-C4 straight-chain or branched alkyl or hydroxyl;the substituent for said substituted 5- or 6-membered aromatic heterocyclic group containing at least one heteroatom selected from N, O or S is C1-C4 straight-chain or branched alkyl;
Z is C, N or O; R9 represents one or more substituents, which are the same or different, and which are each independently selected from the group consisting of H; C1-C4 straight-chain or branched alkyl; benzyl; C1-C4 straight-chain-chain or branched alkyl substituted by one or more groups selected from the group consisting of hydroxyl, oxo and amino; and Y is C, N or 0; R10 represents one or more substituents, which are each independently selected from the group consisting of H, hydroxyl, oxo and C1-C4 straight-chain or branched alkyl; R12 represents one or more substituents, which are each selected from the group consisting of H, hydroxyl, halogen or C1-C4 straight-chain or branched alkyl.