发明名称 Amides of acetic and propionic acids
摘要 The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
申请公布号 US9433614(B2) 申请公布日期 2016.09.06
申请号 US201514633985 申请日期 2015.02.27
申请人 BAYER INTELLECTUAL PROPERTY GMBH 发明人 Luithle Joachim;Bob Frank-Gerhard;Erb Christina;Schnizler Katrin;Flessner Timo;Kampen Marja V.;Methfessel Christoph
分类号 C07D453/02;C07D453/04;A61K31/439 主分类号 C07D453/02
代理机构 Locke Lord LLP 代理人 Locke Lord LLP ;Loren Ralph A.;DiCeglie, Jr. Nicholas J.
主权项 1. A method of treating a cognitive impairment in a patient in need thereof, comprising administering to the patient a compound represented by formula (I) in which R1 is 1-azabicyclo[2.2.2]oct-3-yl optionally substituted by (C1-C6)-alkyl, A is methylene or ethylene, R2 is benzothiophenyl optionally substituted by radicals selected from the group of halogen, formyl, —CO—NR4R5, —CO—OR6, —NR7R8, —NR9—CO—R10, cyano, trifluoromethyl, trifluoromethoxy, nitro, optionally hydroxyl-, amino-, —NH—CO—R11— or cyano-substituted (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylthio, in which R4, R5, R6, R7, R8, R9, R10 and R11 are independently of one another hydrogen, (C1-C6)-alkyl, phenyl or benzyl,and R3 is hydrogen or (C1-C6)-alkyl, or a salt thereof.
地址 Monheim DE