发明名称 |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
摘要 |
Solid forms comprising (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their use are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4. |
申请公布号 |
US9433606(B2) |
申请公布日期 |
2016.09.06 |
申请号 |
US201514670336 |
申请日期 |
2015.03.26 |
申请人 |
Celgene Corporation |
发明人 |
Muller George W.;Schafer Peter H.;Man Hon-Wah;Ge Chuansheng;Xu Jean |
分类号 |
A61K31/40;A61K31/4035;C07C317/28;C07D209/48 |
主分类号 |
A61K31/40 |
代理机构 |
Jones Day |
代理人 |
Jones Day |
主权项 |
1. A method of treating sarcoidosis, the method comprising administering to a patient having sarcoidosis a therapeutically effective amount of a Form B crystal form of the compound of Formula (I):which is enantiomerically pure, and which has an X-ray powder diffraction pattern comprising peaks at about 10.1, 13.5, 20.7, and 26.9 degrees 2θ. |
地址 |
Summit NJ US |