| 主权项 |
1. A method for the reduction of cell proliferation by inhibition of cell cycle progression into S phase by stabilizing the Rb-E2F complex, the method comprising contacting the cell with a synthetic molecular inhibitor of RbN-pocket association, whereby the molecular inhibitor molecule inhibits the interaction between the Rb pocket and Rb N-terminal domain, wherein the synthetic molecular inhibitor comprises an LxCxE motif selected from the group consisting of:SEQ ID No. 1DLYCYEQLNSEQ ID No. 2DLdYCdYEdQLN where dY and dQ are D-tyrosine andD-glutamineSEQ ID No. 3DLYCYEQFNSEQ ID No. 4EDLYCYEQLNSEQ ID No. 5EDLdYCdYEdQLN where dY and dQ are D-tyrosine andD-glutamineSEQ ID No. 6NLFCSEEMDSEQ ID No. 7NLdFCdSEdEMD where dF and dS and dE are D-phenylalanine, D-seriene, and D-glutamateSEQ ID No. 8ELFCSEEMDSEQ ID No. 9ELFCSEEFDSEQ ID No. 10ELFCSEEMR. |
