ALTERED APRIL BINDING ANTIBODIES

摘要

The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.

主权项

1. An APRIL-binding antibody, including an antibody analog, such as an antibody fragment, competing for binding to the same epitope of human APRIL as an antibody, including an antibody analog, such as an antibody fragment, having an antigen binding site of hAPRIL.01A, said APRIL-binding antibody comprising a number of antigen binding sites comprising VH and VL domains, wherein in an antigen binding site the framework sequences of the VH domain have at least 70% sequence similarity with the framework sequences of a VH amino acid sequence selected from SEQ ID NO: 12, 14, 16, 18, preferably SEQ ID NO: 14 or 18 and the framework sequences of the VL domain has at least 70% sequence similarity with the frame work amino acid sequence of SEQ ID NO: 30.