| 发明名称 | Mutations of histone proteins associated with proliferative disorders | ||
| 摘要 | The present application shows the relationship between variations in the amino acid sequence of histone proteins, more specifically the H3.3 protein, and proliferation-associated disorders. Herewith provided are predictive methods, commercial packages, therapeutic methods and screening methods based on this relationship. | ||
| 申请公布号 | US9494591(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201214359900 | 申请日期 | 2012.11.21 |
| 申请人 | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY;UNIVERSITÄTSKLINIKUM HEIDELBERG;GERMAN CANCER RESEARCH CENTER (DKFZ) | 发明人 | Jabado Nada;Pfister Stefan M.;Plass Christoph;Korshunov Andrey;Witt Hendrik;Sturm Dominik;Jones David;Lichter Peter;Pfaff Elke |
| 分类号 | C07K16/18;G01N33/574;C07K14/47;G01N33/68;C12Q1/68;A61K38/00 | 主分类号 | C07K16/18 |
| 代理机构 | Norton Rose Fulbright US LLP | 代理人 | Norton Rose Fulbright US LLP |
| 主权项 | 1. An antibody specific for an isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:6, SEQ ID NO:7, or SEQ ID NO:8. | ||
| 地址 | Montreal CA | ||