| 发明名称 | Anti-FGFR3 antibodies and methods using same | ||
| 摘要 | The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies. | ||
| 申请公布号 | US9499623(B2) | 申请公布日期 | 2016.11.22 |
| 申请号 | US201514887042 | 申请日期 | 2015.10.19 |
| 申请人 | Genentech, Inc. | 发明人 | Ashkenazi Avi;Qing Jing;Wiesmann Christian;Wu Yan |
| 分类号 | A61K39/00;A61K39/395;C07K16/28 | 主分类号 | A61K39/00 |
| 代理机构 | Perkins Coie LLP | 代理人 | Perkins Coie LLP ;Morris Patrick D. |
| 主权项 | 1. A method of treating cancer in a subject in need thereof comprising administering to the subject an anti-FGFR3 antagonist antibody comprising: (i) a light chain variable region comprising (a) HVR-L1 comprising the amino acid sequence of SEQ ID NO:87, (b) HVR-L2 comprising the amino acid sequence of SEQ ID NO:88, and (c) HVR-L3 comprising the amino acid sequence of SEQ ID NO:89, and (ii) a heavy chain variable region comprising (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:84, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:85, and (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:86. | ||
| 地址 | South San Francisco CA US | ||