| 摘要 |
PURPOSE:To obtain the titled gelatin substrate for drug preparation giving an encapsulation film having suppressed hardening phenomenon and delay of disintegration time, by adding a specific amount of cyclodextrin to gelatin. CONSTITUTION:A gelatin substrate produced by adding 10-2wt% cyclodextrin to gelatin. Although various drug preparations prepared by using a gelatin substrate have excellent advantages, they are inferior in stability and disintegrability, etc. Cyclodextrin is a malto-oligosaccharide wherein glucose molecules are linked with each other with alpha-1,4-glycoside bond in the form of a ring. It is composed mainly of 6-8 glucose units corresponding to cyclohexa-, cyclohepta- and cycloocta-dextrin each of which has alpha-, beta- and gamma-isomers. The problems of hardening phenomenon and delay of disintegration time have been solved by the addition of cyclodextrin to gelatin.
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