| 发明名称 |
MANGANESE OR IRON COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE |
| 摘要 |
Low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9, M, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
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| 申请公布号 |
WO9639396(A1) |
申请公布日期 |
1996.12.12 |
| 申请号 |
WO1996US07552 |
申请日期 |
1996.05.31 |
| 申请人 |
MONSANTO COMPANY;NEUMANN, WILLIAM, L.;RILEY, DENNIS, P.;WEISS, RANDY, H.;HENKE, SUSAN, L.;LENNON, PATRICK, J.;ASTON, KARL, W. |
发明人 |
NEUMANN, WILLIAM, L.;RILEY, DENNIS, P.;WEISS, RANDY, H.;HENKE, SUSAN, L.;LENNON, PATRICK, J.;ASTON, KARL, W. |
| 分类号 |
A61K31/395;A61P43/00;C07D259/00;C07F9/6524;C07F13/00;C07F15/02;(IPC1-7):C07D259/00;C07F9/652 |
主分类号 |
A61K31/395 |
| 代理机构 |
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