| 摘要 |
<p>The present invention relates generally to protein molecules with novel binding or catalytic properties. More specifically, the invention relates to the production of libraries of peptide sequences in the framework of a structural template derived from Pleckstrin-Homology (PH) domains and the identification of such sequences that possess the desired properties of binding macromolecular or small molecule ligands, including the transition states of chemical reactions. The invention also relates to the provision of small molecules, derived from the so-obtained peptide sequences that possess ligand binding properties comparable to those of the peptides in the context of the structural framework.</p> |
